Commuters are requested to avoid the tube as several stations are likely to remain closed. Thousands of members of the Rail, Maritime and Transport union (RMT) are staging a 24-hour walkout due to a dispute over jobs and pensions.
Tube lines across the capital will be affected from the start of service on Monday until 8am on Tuesday, with only some services running, Transport for London (TfL) said.
Many stations will be closed, especially those in central and south London, and those that do open may only be in operation for limited periods.
While the DLR, London Overground and TfL’s trams are not impacted, they are expected to be much busier.
Andy Lord, TfL’s chief operating officer, said: “I’d like to apologise to London for the impact this strike will have on journeys tomorrow and on Tuesday morning.
“We know it’s going to be damaging to London and the economy at a time when public transport is playing a crucial role in the capital’s recovery.”
As part of that, TfL has proposed not recruiting into around 500 to 600 existing positions as they become vacant, which the RMT says constitutes lost jobs.
The union argues that working agreements will also be torn up, and that pensions are at risk.
TfL has insisted nobody will lose their job as a result of its proposals, and no changes are on the way for pensions.
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The transport secretary has previously warned that any rail strike could cause a “heart attack” to an industry already on life support.
Mr Lord said: “My message to the RMT is this – it’s not too late to call off tomorrow’s strike action.”