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Statins: How do you wake up in the morning? The 'feeling' that's a common side effect

Subjects rated their energy and fatigue with exertion relative to baseline, on a five-point scale, from “much worse” to “much better”.

Those placed on statins were significantly more likely than those on placebo to report worsening in energy, fatigue-with-exertion, or both.

Both statins contributed to the finding, though the effect appeared to be stronger in those on simvastatin.

“Side effects of statins generally rise with increasing dose, and these doses were modest by current standards,” wrote Beatrice Golomb, MD, PhD, associate professor of medicine at UC San Diego School of Medicine, in the study published in the Archives of Internal Medicine.



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